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Senior Medical Director,

Drug Safety & Pharmacovigilance

for

Senior Medical Director, Drug Safety & Pharmacovigilance

Cambridge, Massachusetts

Reporting to the VP and Head of Drug Safety and Pharmacovigilance, the Senior Medical Director (Sr. MD) will be a member of the Medical Safety Team and taking the role of Product Safety Lead on clinical development program(s) and/or post-marketing products.

You will lead medical assessment and interpretation of safety data from multiple sources including clinical trials, spontaneous and solicited post-marketing reports, aggregate, and literature reports as well as closely collaborating with cross functional teams in supporting all clinical development programs, regulatory filling, and global post marketing Safety related activities as relevant. The Sr. MD will also support PV Operations/Safety System teams and will need to maintain medical knowledge, as well as current knowledge of drug safety and pharmacovigilance regulations, pharmacovigilance practices, safety surveillance and risk-management practices.

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Position Responsibilities

Know About

About
Blueprint Medicines

Blueprint Medicines is a global biopharmaceutical company dedicated to inventing life-changing medicines, focusing on allergy/inflammation and oncology/hematology. Their approach combines deep scientific expertise with modality-agnostic drug discovery capabilities, leading to a proven track record of research and development success.

Blueprint Medicines is advancing a diverse pipeline of investigational therapies targeting mast cell disorders and various cancers. Their research focuses on areas where they are uniquely positioned to drive scientific leadership, pioneer treatment innovation, and improve patient outcomes. They have expanded their scientific platform beyond kinase inhibitors to include additional modalities, such as targeted protein degradation, and have incorporated state-of-the-art translational medicine capabilities and new technologies, including artificial intelligence and machine learning tools, to enhance the productivity and efficiency of their drug discovery efforts.

Blueprint Medicines achieves impactful results because of their global crew of compassionate innovators – the Blue Crew. Through authentic relationships and  collective entrepreneurial spirit and action, they are each empowered to take ownership and execute with strategic prioritization. They put trust in their people to break through norms and conventions using their individual strengths and insights, which drives Blueprint’s success.

Product
Pipeline

Blueprint Medicines is advancing a diverse pipeline of therapies targeting mast cell disorders and solid tumors. Here’s an overview of their current programs:

Mast Cell Disorders:

  • AYVAKIT® (avapritinib): A KIT D816V inhibitor approved in the U.S. for adults with indolent systemic mastocytosis (SM) and advanced SM, including aggressive SM (ASM), SM with an associated hematological neoplasm (SM-AHN), and mast cell leukemia (MCL). 

  • Elenestinib (next-generation KIT D816V inhibitor): Currently in late-stage development for indolent SM.

  • BLU-808 (wild-type KIT inhibitor): In early-stage development for mast cell disorders.

Solid Tumors:

  • AYVAKIT (avapritinib): Approved in the U.S. for adults with unresectable or metastatic gastrointestinal stromal tumors (GIST) harboring a PDGFRA exon 18 mutation, including PDGFRA D842V mutations.

  • BLU-956 (next-generation CDK2 inhibitor): In the discovery phase, targeting hormone receptor-positive (HR+), HER2-negative breast cancer.

  • Targeted protein degraders:

    • CDK2 degrader: In discovery for HR+, HER2- breast cancer. CDK4 degrader: Also in discovery for HR+, HER2- breast cancer. 

Advancing life sciences with expert talent.

Christina Cagle

I am a dedicated advocate for scientific innovation, serving as a strategic partner and collaborator. My mission is to bridge vision with execution, driving breakthroughs that transform lives. Let’s work together to shape a future where science fuels progress and creates a lasting impact.

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